Fresh analysis suggests that patients who stop using new slimming jabs like semaglutide or tirzepatide tend to recover reduced body mass much more quickly than those who halt traditional lifestyle regimens.
Findings released in a major medical journal shows that while obese individuals frequently drop a large proportion of their body weight while using the jabs, the weight comes back at an estimated rate of 0.8 kg per month after stopping.
"Users purchasing such medications must be aware of the danger of quick rebound weight gain when the therapy is stopped," warns expert Dr. Susan Jebb.
Such speed of regain suggests a reversion to original weight within about 18 months.
Weighing Treatments
The study, which reviewed 37 of trials involving over 9,000 of patients, contrasted the outcomes of these new drugs with conventional dieting.
Researchers note that individuals who lose weight through dieting typically experience a more gradual creep back—perhaps 100 grams monthly—post-intervention.
Understanding the Fast Rebound
Doctors propose the way of the injections is key to understanding the heightened regain.
The injections mimic a natural hormone called glucagon-like peptide-1, which controls appetite.
"Sustained high doses of the hormone concentrations several times higher than normal may cause the body to generate a reduced amount of its own natural GLP-1, and may also diminish responsiveness to its actions," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this hormone supplement leads to appetite is no longer kept in check, making overeating a significant risk."
An Ongoing Disease?
The NHS suggest the jabs for people with obesity-related health risks, alongside prescribed lifestyle changes.
Professionals argue that, considering the likelihood of relapse, the therapy is often ongoing.
This view is echoed by drug manufacturers, who note that the findings "highlight the long-term character of obesity," akin to managing conditions like hypertension.
Patient Accounts
Individuals who have come off the jabs explain a intense resurgence of hunger.
"I experienced a switch activating and you're instantly extremely hungry," described an individual.
This challenge is worsened if users have not developed permanent dietary or behavioural modifications during therapy.
Growing Adoption
Figures suggest that a significant number of people in the UK have tried weight-loss jabs in the past year, with desire continuing to grow.
- Adoption is greater among females than males.
- The 40s and 50s demographic shows the highest level of interest.
- A large proportion access the drugs through private healthcare rather than public health services.
Ultimately, researchers emphasize that while these medications are potent tools for shedding pounds, they are not a magic fix and lasting health benefits relies on combined behavioural management.
